8,083 research outputs found
Bayesian Analysis of Simple Random Densities
A tractable nonparametric prior over densities is introduced which is closed
under sampling and exhibits proper posterior asymptotics.Comment: 19 pages; 6 figure
Predictive analysis of microarray data
Microarray gene expression data are analyzed by means of a Bayesian
nonparametric model, with emphasis on prediction of future observables,
yielding a method for selection of differentially expressed genes and a
classifier
Effect of particle polydispersity on the irreversible adsorption of fine particles on patterned substrates
We performed extensive Monte Carlo simulations of the irreversible adsorption
of polydispersed disks inside the cells of a patterned substrate. The model
captures relevant features of the irreversible adsorption of spherical
colloidal particles on patterned substrates. The pattern consists of (equal)
square cells, where adsorption can take place, centered at the vertices of a
square lattice. Two independent, dimensionless parameters are required to
control the geometry of the pattern, namely, the cell size and cell-cell
distance, measured in terms of the average particle diameter. However, to
describe the phase diagram, two additional dimensionless parameters, the
minimum and maximum particle radii are also required. We find that the
transition between any two adjacent regions of the phase diagram solely depends
on the largest and smallest particle sizes, but not on the shape of the
distribution function of the radii. We consider size dispersions up-to 20% of
the average radius using a physically motivated truncated Gaussian-size
distribution, and focus on the regime where adsorbing particles do not interact
with those previously adsorbed on neighboring cells to characterize the jammed
state structure. The study generalizes previous exact relations on monodisperse
particles to account for size dispersion. Due to the presence of the pattern,
the coverage shows a non-monotonic dependence on the cell size. The pattern
also affects the radius of adsorbed particles, where one observes preferential
adsorption of smaller radii particularly at high polydispersity.Comment: 9 pages, 5 figure
Characterization of a rare analphoid supernumerary marker chromosome in mosaic
Abstract publicado em: Chromosome Research. 2015;23(Suppl 1):67-8. doi:10.1007/s10577-015-9476-6Analphoid supernumerary marker chromosomes (SMCs) are a rare subclass of SMCs C-band-negative
and devoid of alpha-satellite DNA. These marker chromosomes cannot be identified unambiguously by conventional banding techniques alone being necessary to apply molecular cytogenetic methods in favour of a detailed characterization. In this work we report an analphoid SMC involving the terminal long arm of chromosome 7, in 9 years-old boy with several dysmorphic features and severe development delay.
Cytogenetic analysis revealed a mosaic karyotype with the presence of an extra SMC, de novo, in 20 %
of lymphocytes and 73 % of fibroblast cells. FISH analysis with alpha-satellite probes for all chromosomes, whole chromosome painting probe for chromosome 7, and D7S427 and TelVysion 7q probes, allowed
establishing the origin of the SMC as an analphoidmarker resulting of an invdup rearrangement of 7q36-qter region. Affimetrix CytoScan HD microarray analysis, redefined the SMC to arr[hg19] 7q35(143696249-159119707)×2~3, which correspond to a gain of 15.42 Mb and encloses 67 OMIM genes, 16 of which are associated to disease. This result, combined with detailed clinical description, will provide an important means for better genotype-phenotype correlation and a more suitable genetic counselling to the patient and his parents, despite the additional difficulty resulting from being a mosaic (expression varies in different tissues). Analphoid SMCs derived from chromosome 7 are very rare, with only three cases reported so far. With this case we hope contribute to a better understanding of this type of chromosome rearrangements which are difficult for genetic counselling
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